Sunday, July 22, 2012

Investing in Stocks 101

10:04 am Investing

Stocks are also known as equities. Equities are a semi-liquid investment, this means that money can be moved into and out of stocks pretty easily.?Stocks?are generally considered to be a risky investment, however there are ways that you can invest in stocks and make a large return. Options are contracts to buy or sell stock at a given price (?strike price?) these contracts can help prevent loss, but also bear a risk of their own. Options contract trading should be left to the skilled investor, who knows what he or she is doing. The more skill you obtain in trading stocks, the larger your return prospective can be.?

Source: http://www.downtownlakezurich.org/investing/investing-in-stocks-101/

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Police set off blast inside shooting suspect's apartment

An explosion can be heard coming from the apartment of suspected Colorado movie theater gunman James Eagan Holmes' apartment.

By Miranda Leitsinger and Miguel Llanos, NBC News

AURORA, Colo. -- Specialists set off a small, controlled detonation inside the apartment of mass shooting suspect James Eagan Holmes on Saturday after earlier disarming a trip wire and incendiary device set to kill, police said.

The blast succeeded in disarming a second triggering device,?Aurora Police Sgt. Cassidee Carlson told reporters.

A siren and shouts of "Fire in the hole" preceded the blast, and a two-man team on a fire truck ladder later peered inside the third-story apartment. Live video showed the blast blowing out part of a window, but no smoke or fire resulted.

"The controlled detonation was successful," the Aurora Police Department said in a statement. "Still more work to be done in the apartment to include dealing with other devices. There is a possibility of more controlled detonations."

The 800-square-foot apartment appears to have three types of explosives, a law enforcement source told the Associated Press: jars with accelerants; chemicals that would explode when mixed together; and more than 30 "improvised grenades" that resemble commercially available aerial fireworks shells.


Before the detonation, Carlson announced a trip wire and explosive had been disarmed, saying "we have been successful in defeating the first threat."

"It was set up to kill," she said of the trip wire and explosive.

She did not say if the team used a robot as earlier planned.

She added that "another triggering mechanism" had been found inside, and that was later followed up with the controlled detonation.

Carlson earlier said any controlled detonation "may cause a loud boom. There may also be a fire that erupts at that point."

"We're going to be very cautious," she added, because "we don't want to lose" any evidence.

Authorities in Aurora, Colo., announce that they have completed the first step needed to enter the apartment of suspected movie theater shooter James Eagan Holmes.

"There are still unknowns," she said, referring to the possibility of a fire or explosions that are not controlled. "We're not exactly sure of everything that's in there."

Any undetonated explosives will be taken in trucks lined with sand to take the impact of any explosion, she said, adding that some 30 aerial shells are among the items detected inside the apartment on Friday.

Fire trucks surrounded the building on Saturday as a precaution. Some adults and children in nearby?buildings not evacuated watched from balconies.

Earlier Saturday, streets around the building were cleared, four neighboring buildings were evacuated and some unattended vehicles were towed away.

On Friday, tenants in Holmes' apartment building cleared out, taking with them a few belongings.

The Red Cross said Saturday that 16 evacuees were in one of the agency's shelters.

The building is in a lower-income area about four miles from where the shootings took place during a midnight premiere of the Batman movie "The Dark Knight Rises".

James Holmes was described as a geeky, booksmart and quiet student. Now, police are trying to figure out what caused him to allegedly commit such a heinous act.

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Source: http://usnews.msnbc.msn.com/_news/2012/07/21/12875178-police-set-off-blast-inside-colorado-theater-shooting-suspects-apartment?lite

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Saturday, July 21, 2012

12 Tips for Gently Parenting Your Adult Children (Hint: It starts when ...

?Life is a succession of lessons which must be lived to be understood.? ~Ralph Waldo Emerson

As a mother of six?from 25 years old all the way down to 25 months old, three of whom are adults, two of them married, one?with two small children, three with college degrees, one?a Pastor, one?a Family Therapist, one a senior pre-med student, two who are teenagers, two currently homeschooled, one a kindergartener, and one a diaper-bottomed nursing toddler, my ?boots on the ground? parenting experience is not only wide-ranged, but also very current for nearly every stage of parenting possible.

I have also studied developmental and educational psychology, have more than two decades of training and experience in leading and developing student and children?s ministries, have created curriculums for both home education and church-based learning centers, have trained in, worked in, and directed early childhood education programs, worked with high-risk youth as a leader and mentor, and have extensive experience as a parenting author, speaker, and coach.

None of those things, however, make it okay for me to over-step my boundaries as a parent of adult children who are just embarking on their careers, just beginning to make their mark on the world, just establishing their own families.

So, what are my boundaries? That, friends, is the 64,000 dollar question.

All stages of parenting come with their own unique learning curve, their own challenges and frustrations, their own compromises and sacrifices, and their own flubs, false steps, and failures. From those first terror-stricken days with a newborn to the sleep-deprived months of infancy to the challenges of toddlerhood and beyond, parenting is a journey, not a destination. And when subsequent little ones arrive, the journey starts all over again as we discover that the lessons learned from parenting one child don?t always apply to the next as each have their own incomparable personalities, quirks, and individual identities.

The principles of gentle parenting (i.e. connection, empathy, intentionality, respect) don?t change as our children grow, just as they don?t change from one child to the next. What does change is our understanding of those principles as we grow in wisdom and experience as parents and human beings. The practical application of gentle parenting principles, though, can look very different from child to child and life stage to life stage. For instance, with an introverted child gentle parenting might involve a greater degree of physical proximity and emotional support whereas with a very extroverted child it may involve a greater degree of energy direction and respectful guidance.

This constancy of principles and individualized application of gentle parenting is no less true when parenting our adult children than it is when parenting our minor children. As gentle parents, we are our children?s first and best friend in the purest and truest definition of friendship. That sets the stage for the transition from the early parent/friend years to the parent-friendship that will characterize our relationship when our children grow into adulthood.

Here are 12 practical tips for gently parenting your adult children:

1.)??? Begin to consciously pay attention to your own parents? interactions with you. Mentally catalogue what you find helpful and what you find intrusive, what is an acceptable level of involvement, advice, and interaction and what feels overbearing or lacking. Make a mental (or actual!) note to remember those feelings when your own children become adults.

2.)??? Remember, parenting is literally ?on the job? learning. Your parents are discovering by trial and error (often lots of error) what their roles and boundaries are in this uncharted territory of parenting adults. Model giving your parents grace when they overstep or underplay their roles. This will set the stage for your children to extend the same grace to you when seemingly overnight you suddenly find yourself learning to parent your own adult children.

3.)??? While your child is an infant, meet their needs swiftly, consistently, and gently. They won?t remember what you did or didn?t do at this stage, but they will always carry with them how it made them feel. Make sure what they feel is safe, secure, and loved so that is they will take with them into adulthood.

4.)??? When your child reaches toddlerhood, focus on connection rather than correction. What will matter most in later years won?t be whether they wore matching shoes or left the park without pitching a fit. What will matter is whether they felt heard, understood, and respected.

5.)??? As your child moves into the preschool and early childhood years, focus on communication, whether that takes the form of whining, tattling, endless questions or some combination of all three. Continue to build a trust relationship by hearing their heart rather than their tone and responding with gentle guidance.

6.)??? When your child reaches the middle stages of childhood, listening to the endless stories from your chatterbox or offering empathy and quiet support to your dreamer will help them as they explore who they are and who they want to be when they grow up. You are building the friendship of a lifetime in these interactions, so make them a priority!

7.)??? Once your child enters the teen years, consciously begin to gradually shift your role into a supporting rather than a leading act. Listen not to their words, their attitudes, their hormones, their angst. Listen instead to their struggles, their hopes, their dreams, their fears. Remember, you are the only adult in the relationship at this point. They still have a lot of maturing to do. Practice self-control. Be honest about your own struggles, fears, and failings. You?ll be amazed at what a connection point that is as your teen discovers that they aren?t alone in their humanness. Be the first one to listen, the first one to forgive, the first one to apologize, the first one to understand, the first one to back down and try to find another way when the going gets tough.

8.)??? When your child becomes an adult, let them set the pace. Some children will hit eighteen and be ready to move into a university dorm or get a job and an apartment right away. Others will need a slower transition. They may need to stay at home while going to university or while taking some time to try out different jobs as they explore this strange new world of adulthood. If the time comes that you feel they need a gentle nudge out of the nest, you can help them to find an acceptable roommate or two and guide them through the process of settling into independent adulthood.

9.)??? Once your child is out on their own, your role will shift fully to a support system. Offering unsolicited advice is fine as long as it is briefly stated?once. After that, it becomes intrusive. Offers of help and invitations to family events, etc. should follow the same guidelines.

10.)??? When your child starts a family of their own, consciously bring to mind how you felt at various times when your own parents supported you in your new role and/or interfered with the establishment of your new little family. Acknowledge to yourself and to them that they won?t do everything the way you did, that they will make decisions you wouldn?t make, that you will offer advice that won?t be heeded, and that they will make mistakes and have to learn from them just like you did.

11.)??? On the subject of making mistakes, remember, just as you wouldn?t want every youthful mistake, every wrong choice, every unfortunate decision to be broadcast to the world or even just joked about privately instead of being left in the past where it belongs,?be sure to practice ?The Golden Rule of Parenting? and treat your children how you like to be treated.

12.)??? Keep in mind that the person you are now isn?t the person you were when you first started out on your journey into adulthood. Expecting your young adult children to think and experience and process life and events the way that you do now is like expecting a newborn baby to be able to pick up a book and read it.

Remember, the voice of experience has an immense amount of wisdom to offer, but only if it also has the wisdom to know when to remain silent. ~L.R.Knost

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Related posts:

Your Baby isn?t Trying to Annoy You; He?s Trying to Communicate!

Tots to Teens~Communication Through the Ages and Stages

A Boy, A Girl, and A Baby~Journey to Gentle Parenting

Mona Lisa Smiles

The Trouble with Kids Today

Toddlers: Teens in the Making

The Measure of Success~Chinese Parents and French Parents Can?t BOTH Be Superior!

Spare the Rod: The Heart of the Matter

In Cold Blood

Practical Gentle Discipline

Holy Communication, Batman!

Source: http://www.littleheartsbooks.com/2012/07/20/12-tips-for-gently-parenting-your-adult-children-hint-it-starts-when-theyre-newborns-2/

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everyone of our techs are truly experienced in repair and fitting of office and home AC unit and heating unit equipment. Our techs are on top of all changes in tech from heat systems to air conditioning, selling today. giving you comfort is company aim? ? comfortableness with the units we provide and the system that will expeditiously serve you for lot?s years.

We will make sure your heating and chill unit is operating at best function to save you spending, improve your well-being, and make you are content! We are Air Conditioning professionals.

Source: http://informallearning.org/Blog/2012/07/20/air-conditioning-servicing-culver-city-2/

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Applying Information Technology Education in the Real World ...

Students partner with professional technology center to fix computers

By Ashley Stopperan

Eight students enrolled in the Information Technology degree program at the Minnesota School of Business (MSB) ? St. Cloud campus applied what they learned in the classroom by repairing computers for people in their community. Students in the Computer Essentials course led the ?Computer Bug and Repair Clinic? on May 24, 2012. Previously, the clinic was only available for staff, faculty members and other students to attend, but this year it was opened up to the public.

Partnering with Minco, a professional technology center, students broadened the clinic?s reach and helped community members solve their computer or laptop problems for free. The clinic provided the students with real-world experience in which they learned the importance of professionalism, customer service and work efficiency.

MSB-St. Cloud IT students

Minnesota School of Business-St. Cloud IT students learn to build their own computers

The eight students identified procedures and components, reassembled computers, repaired problems associated with each component and gave knowledgeable recommendations.

?They got a chance to fix and repair many computers, which was a very rewarding experience,? said Tom Polinceusz, IT Program Chair at MSB-St. Cloud. ?I always look for opportunities for my IT students to apply the skills that they learn in classroom.?

Minco has hired many MSB graduates over the years and has always been very satisfied with their IT skills and knowledge.?Minco provided great support during the clinic and supplied any new parts that specific repairs required. MSB and Minco continue to maintain a strong relationship, especially with Minco Sales Representative, Jim Draper, who is also a member of MSB-St. Cloud?s Program Advisory Committee.

Over the span of four hours, many people dropped off a broken computer and left with one that worked again.? ?Overall it was a great success,? Tom added.

This entry was posted in Uncategorized. Bookmark the permalink.

Source: http://blogs.msbcollege.edu/2012/07/20/applying-information-technology-education-in-the-real-world/

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Friday, July 20, 2012

Colorful science sheds light on solar heating

ScienceDaily (July 19, 2012) ? A crucial, and often underappreciated, facet of science lies in deciding how to turn the raw numbers of data into useful, understandable information -- often through graphs and images. Such visualization techniques are needed for everything from making a map of planetary orbits based on nightly measurements of where they are in the sky to colorizing normally invisible light such as X-rays to produce "images" of the sun.

More information, of course, requires more complex visualizations and occasionally such images are not just informative, but beautiful too.

Such is the case with a new technique created by Nicholeen Viall, a solar scientist at NASA's Goddard Space Flight Center in Greenbelt, Md. She creates images of the sun reminiscent of Van Gogh, with broad strokes of bright color splashed across a yellow background. But it's science, not art. The color of each pixel contains a wealth of information about the 12-hour history of cooling and heating at that particular spot on the sun. That heat history holds clues to the mechanisms that drive the temperature and movements of the sun's atmosphere, or corona.

"We don't understand why the corona is so hot," says Viall who wrote about this technique and her conclusions about the corona in a paper that recently appeared in The Astrophysical Journal. "The corona is 1,000 times hotter than the sun's surface, when we would expect it to get cooler as the atmosphere gets further away from the hot sun, the same way the air gets cooler further away from a fire."

Scientists generally agree that energy in the roiling magnetic fields of the sun must transfer energy and heat up into the atmosphere, but the exact details of that process are still debated. Viall created her technique to see if she could distinguish between theories that describe coronal heating as uniform over time, versus those that say it comes from numerous nanoflares on the sun's surface.

To look at the corona from a fresh perspective, Viall created a new kind of picture, making use of the high resolution provided by NASA's Solar Dynamics Observatory (SDO). SDO's Atmospheric Imaging Assembly (AIA) provides images of the sun in 10 different wavelengths, each approximately corresponding to a single temperature of material. Therefore, when one looks at the wavelength of 171 Angstroms, for example, one sees all the material in the sun's atmosphere that is a million degrees Kelvin. By looking at an area of the sun in different wavelengths, one can get a sense of how different swaths of material change temperature. If an area seems bright in a wavelength at shows a hotter temperature an hour before it becomes bright in a wavelength that shows a cooler temperature, one can gather information about how that region has changed over time.

To study such temperature changes, many scientists focus on analyzing a specific subset of solar material, such as giant arcs of charged particles that leap up off the sun's surface called coronal loops. Scientists gather information about the loops by comparing nearly simultaneous images of the sun in different wavelengths. Analysis of the loops in each image requires time-consuming, manual analysis to subtract the background observations away from the loops themselves, a process which is also inherently subject to human judgment and bias. In addition, each individual image represents light from only a narrow range of wavelengths, representing material at a narrow range of temperatures.

Viall wanted to look at as much of the solar material in a given area of the corona as she could, incorporating information about a variety of temperatures simultaneously. She also wanted to avoid the subjective process of subtracting out the background. Instead, she decided to look at all light coming from a given spot on the sun at the same time. That meant coming up with a visualization technique to convey all that information at once -- and thus her Van Gogh-like images were born.

For an interesting spot on the sun, Viall examines six channels over an entire 12-hour stretch. She compares each channel to the other channels in turn, assigning it a red, orange, or yellow color if the area has cooled, and assigning it a blue or green color if the area has heated up. She assigns the exact shade of the color based on how much time it took for the temperature change to occur.

"In essence, I'm measuring the time lag of how long it takes a given area to heat up or cool down," says Viall. "But it's totally automated, with no need for humans to make a decision about what to incorporate or ignore. And all of the solar material is represented statistically, not just one wavelength of light."

Viall's images show a wealth of reds, oranges, and yellow, meaning that over a 12-hour period the material appear to be cooling. Obviously there must have been heating in the process as well, since the corona isn't on a one-way temperature slide down to zero degrees. Any kind of steady heating throughout the corona would have shown up in Viall's images, so she concludes that the heating must be quick and impulsive -- so fast that it doesn't show up in her images. This lends credence to those theories that say numerous nanobursts of energy help heat the corona.

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Story Source:

The above story is reprinted from materials provided by NASA/Goddard Space Flight Center.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Nicholeen M. Viall, James A. Klimchuk. PATTERNS OF NANOFLARE STORM HEATING EXHIBITED BY AN ACTIVE REGION OBSERVED WITHSOLAR DYNAMICS OBSERVATORY/ATMOSPHERIC IMAGING ASSEMBLY. The Astrophysical Journal, 2011; 738 (1): 24 DOI: 10.1088/0004-637X/738/1/24

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/NVKbsios1i8/120719212741.htm

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Making Your House More Livable through Some Home Improvement

Home improvement project can be done in many different ways. In fact, making a home improvement project can be a sort of hobby and even a passion to others. Improving your house also means that you increase its value and usability. When you are improving your house, sometimes it cost you a lot but the results are worth it in the end. So when you indulge yourself to this kind of task, you need to consider several things for making good decisions and to keep you in the right track.

Here are some home improvement projects you can make when you are improving your own house.

One way to refresh the look of your home is to put some colors through applying a new coat of paint. Repainting your house enhances its appeal. One of the most effective ways to improve the appearance of your home through painting also adds more value to your property. If you want to make your property more livable and comfortable, use a coat of paint that is pleasing to the eyes. If you plan to resell your property, neutral colors of paint are best option.

Improving the lighting system. As home owners, we always want our house to look brighter. Adding more lights to some areas of our house can be a good home improvement project. Installing extra lights to hallways, dining room, living room, and other important areas also means of giving more value to your own masterpiece. On the other hand, one way to save money and increase the brightness of the house is by using LED lights. LED bulbs often saves energy up to 90 percent and less hazardous.

Organize your furniture and other stuff. If you are fond of collecting and displaying things and adding furniture to your house then it is also necessary to organize them on a regular basis. Removing some furniture that is no longer useful and arranging some decors on your walls and ceilings are ways on how to improve the looks of your home. Put some emphasis on how you move and organize them properly. Just make sure you never waste your time and know your budget for these things.

Landscaping is an option. One thing that adds color to your property is improving its landscape. If you have knowledge on how to improve the design of your landscape then that would be a better move. Add some lights and even a great piece of decor to your yard and ground areas. These can be some ways to increase the attractiveness of your home, too.

These are simple home improvement projects that will guide you and boost your confidence you need to take on and prepare yourself for bigger projects ahead. Remember that it?s possible to turn your home into a beautiful masterpiece and make it more livable.

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Source: http://saltlake.countyutahrealestate.com/2012/07/making-your-house-more-livable-through-some-home-improvement-projects/

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Exit Interviews? Why Not Do Stay Interviews? | Business 2 Community

Here?s an interesting thought: Why do companies conduct exit interviews when employees leave, but they don?t conduct stay interviews to understand why employees stay?

Think about this. Companies often focus on churn or attrition of customers ? or turnover for employees ? but who has retention as a key metric? I?ve worked with a lot of clients who track customer or member attrition on their scorecards but not retention. Why not? I just met with a client last week who conducted nothing else but Lost Customer research. It accounted for 4% of their business! Why aren?t they focusing on the 96% that remain and what it takes to keep them?!

OK. This post is about employees. I?ll devote a full blog in the future to customer retention and attrition. But, just as we know that employee engagement drives customer engagement, we can also surmise that employee retention drives customer retention. Why? Well, for one, because people buy from people! Those human relationships are so vital!

I don?t even think I need to pose this, but why focus on employee retention instead of turnover? Without a doubt, employee turnover is costly ? not just in terms of the costs of recruiting, hiring, and training a new person but also in terms of the knowledge and productivity that just walked out the door.

So, let?s think about this for a second. In an exit interview, we typically ask what went right and what went wrong. (I?m over-simplifying, but you get the point.) At this juncture in the employee-employer relationship, where the employee has checked out, the employee has no vested interest (usually), and either doesn?t provide any information worth acting on (sometimes for fear of recourse) or does such a huge dump of things gone wrong that you find it hard to believe, i.e., is it vendetta or truth? It?s too late to save the employee, which can be a costly mistake. Honestly, I?m not so sure that an exit interview is a good use of time and resources. I do, however, like the concept of the stay interview.

Why don?t we ask, on a regular basis, where employees stand; how they feel about the organization, management, culture, and vision/direction; and if they have everything they need to be successful in their roles? You might say, well, I do an employee satisfaction survey. Isn?t that good enough? I say ?Bravo to you!? if you do conduct employee satisfaction surveys! You?re ahead of the curve already! Stay interviews are a bit different, though, and supplement your annual or semi-annual employee survey. They are more conversational in nature and are conducted between manager and employee, perhaps during weekly 1:1s.

While exit interviews are more like autopsies in nature, stay interviews are more like your wellness visits, focusing on what current employees enjoy about working for the company, as well as on aches and pains and what needs to be fixed. As an employee is walking out the door, there is really nothing that a manager can correct immediately to keep him, while employees who are staying can be reassured that they are appreciated and can witness their feedback being used to transform the organization and its culture.

Key to this process is that managers are trained on how to conduct the interviews and how to address concerns and feedback. Also important is the need to close the loop and keep employees abreast of improvements and changes as a result of the discussions. Changes, if needed, must be made in order for this to be a successful initiative. In addition, these discussions must happen on an ongoing basis. Paramount to everything else is a culture that accepts the feedback gleaned from these interviews without recourse and embraces employees who are open and honest, in the spirit of success of the company.

Let me know if your company conducts stay interviews. I?m curious to find out how they are received and how they are used. Are they ongoing discussions? Are they successful?

?Planning is bringing the future into the present so that you can do something about it now.??~Alan Lakein

Source: http://www.business2community.com/strategy/exit-interviews-why-not-do-stay-interviews-0225644

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2012 Sundance Institute Creative Prod Labs: ?Bright As Day ...

While not all films mentioned below are necessarily guaranteed future place among the Sundance Film Festival elite,? it?s certainly a step in the right direction for the filmmakers and more importantly the producers backing the future of independent film. Among the eleven project participants below selected for the annual Creative Producing Labs and Creative Producing Summit (July 30 ? August 3) in the Feature Film category we find such names as future superstars in Summer Shelton (she worked with Ramin Bahrani) and receives the first ever Bingham Ray Creative Producing Fellow, Tory Lenosky (worked as an assistant to?Jay Van Hoy and Lars Knudsen) and Lucas Joaquin (second unit producer for Beasts of the Southern Wild). Here is the full press release below.

FEATURE FILM CREATIVE PRODUCING LAB
The Feature Film Creative Producing Lab is a five-day Lab where narrative feature film producers work with an accomplished group of Creative Advisors to develop their creative instincts, communication and problem-solving skills in all stages of film production. This year?s Creative Advisors include producers Anne Carey (The American, Adventureland), Karin Chien (Circumstance, Exploding Girl), Lynette Howell (Terri, Blue Valentine) and Paul Mezey (Beasts of the Southern Wild, Sugar).

The Fellows and projects selected for the Feature Film Creative Producing Fellowship are:

Bright As Day
Mark Silverman Honorees & Producing Fellows: Lucas Joaquin & Tory Lenosky
Against the backdrop of the recent London riots, a disaffected teenager finds refuge from the adult world as she bonds with a run-down horse. (Writers/Directors: Eleanor Burke & Ron Eyal)

Tory Lenosky and Lucas Joaquin are New York-based producers who most recently worked together on Keep the Lights On with Lucas as Producer and Tory as Line Producer. Lucas served as the second unit Producer for Beasts of the Southern Wild and produced the acclaimed short film Last Address, which screened at the 2011 Venice Biennale and is now in the permanent collection at the Whitney Museum of American Art and the Museum of Modern Art in New York. Tory began her career as an assistant to Jay Van Hoy and Lars Knudsen at Parts and Labor and moved her way up the production ranks working on films such as Beginners, Here and Lovely Still.

Hellion
Producing Fellow: Kelly Williams
In small-town Texas, when thirteen-year old Jacob?s delinquent behavior gets his brother taken away, he?ll go to extreme, destructive lengths to bring him home. (Writer/Director: Kat Candler)

Kelly Williams is an Austin-based producer and the Director of Programming at the Lone Star International Film Festival in Fort Worth, Texas. Kelly served as the Program Director of the Austin Film Festival for eight years where he programmed features and shorts, as well as overseeing the full scope of the festival?s programming. Kelly produced the short film Perils in Nude Modeling, which screened at over 100 festivals and was a Student Academy Award nominee and in 2011, he produced two feature films, Pictures of Superheroes and Cinema Six, as well as the short film Hellion, which premiered at the 2012 Sundance Film Festival.

Joy of Living
Sheila C. Johnson Producing Fellow: Ashley Maynor
A lonely detective investigating a piano teacher?s murder forges an unlikely friendship with one of the victim?s former students who has returned to the South to help solve the case. (Writer/Director: Paul Harrill)

Ashley Maynor is a Tennessee-based filmmaker and producer. She produced the ITVS co-production Quick Feet, Soft Hands, starring Greta Gerwig, and the forthcoming feature, Something, Anything, both written and directed by Paul Harrill. She frequently blogs at Self-Reliant Film (www.selfreliantfilm.com), a website that supports regional, DIY, and personal filmmaking. In June 2012, Maynor began work as a managing producer at Nest Features, a newly-launched company dedicated to producing films in the American South.

Life Partners
Steve Bing Producing Fellow: Jordana Mollick
A straight girl drunkenly promises her lesbian best friend she won?t get married until gay marriage is legal? a promise that gets awkward when her boyfriend proposes and her friend remains a slacker years away from even thinking about marriage. (Writers: Susanna Fogel & Joni Lefkowitz, Director: Susanna Fogel)

Jordana Mollick began her career in New York theater where she worked at the Endeavor Agency honing her skills in development. Jordana then went on to serve as the development executive for writers Brian Koppelman and David Levien (Rounders, Runaway Jury, Ocean?s 13). Upon moving to Los Angeles, she then formed her own management company Black Sheep Entertainment, which aims to develop a diverse slate of films and manage a carefully curated array of writers and directors. Under Black Sheep, Jordana created the annual Unscreened play series, which is where Life Partners was seeded. Life Partners was also a participant in the 2012 January Screenwriters Lab.

Untitled Amazon Project
Bingham Ray Producing Fellow: Summer Shelton
When a lumber conglomerate evicts their family, two brothers attempt to smuggle exotic lumber in hopes of selling it on the black market for money to buy their family new land, but what begins as a hopeful act turns into a journey more dangerous than they imagined. (Writer/Director: Alex Moratto)

Summer Shelton is a freelance producer born and raised in North Carolina who often works with critically acclaimed director Ramin Bahrani, having been the Associate Producer of his upcoming feature At Any Price (2012) starring Dennis Quaid and Zac Efron, Goodbye Solo (2008), an official selection of the Venice Film Festival that won the FIPRESCI International Critics Prize for Best Film, and Co-Producer of his short Plastic Bag (2009). She is the Co-Producer of Scott Coffey?s upcoming feature Adult World (2012) and has worked as a production manager and coordinator on various independent films.

DOCUMENTARY FILM CREATIVE PRODUCING LAB
The Documentary Film Creative Producing Lab is a five-day Lab where Sundance Institute Documentary Film Program and Fund grantees are invited to work intensively with award-winning Creative Advisors to hone the craft of producing documentaries. The Lab includes workshops on financing, production and creative distribution for documentary films. This year?s Creative Advisors include Bonni Cohen (Producer, The Island President), Jess Search (CEO, BritDoc Foundation), publicist Nancy Willen (Acme PR) and sales agent Josh Braun (Submarine Entertainment).

The Fellows and projects selected for the Documentary Film Creative Producing Lab are:

Dirty Wars: The World is a Battlefield
Producing Fellows: Anthony Arnove and Brenda Coughlin
Reporting from the battlefields of the war on terror, journalist Jeremy Scahill investigates the wars waged by and against an empire, and constructs a global picture of asymmetric warfare today.

Anthony Arnove and Brenda Coughlin are co-founders of the non-profit media company Civic Bakery. They co-created and produced The People Speak with Howard Zinn, Chris Moore, Josh Brolin and Matt Damon, the documentary film companion to Howard Zinn?s bestselling book A People?s History of the United States.

Solarize This (working title)
Producing Fellow: Shalini Kantayya
In a city where oil spills, air quality red-alerts, and poverty are commonplace, Solarize This asks the hard questions of how a clean energy economy may actually be built, from the perspective of three unemployed American workers seeking to retool at a solar jobs training program in Richmond, California.

Brooklyn-based filmmaker and eco-activist Shalini Kantayya finished in the top 10 out of 12,000 filmmakers on Fox?s ON THE LOT, a show by Steven Spielberg in search of Hollywood?s next great director. Her work has screened at over forty festivals internationally. ?Shalini received an MFA in Film Direction from the City College of New York, and a BA in Media Studies and International Human Rights from Hampshire College.

These Birds Walk
Producing Fellows: Omar Mullick and Bassam Tariq
A portrait of contemporary Pakistan is created through the eyes of a runaway boy and an ambulance driver who call a dying humanitarian and his struggling organization home.

Omar Mullick and Bassam Tariq?s articles and photographs have been published widely in National Geographic. The New York Times, Time Magazine and Democracy Now! These Birds Walk is their feature documentary debut.

The New Black
Producing Fellow: Yoruba Richen
The New Black is a documentary that uncovers the complicated and often combative histories of the African-American and LGBT civil-rights movements.

Yoruba Richen is a Harlem-born, Brooklyn-based documentary filmmaker. She has directed and produced films in the U.S. and abroad including Africa, South America and Southeast Asia. Her award?winning documentary Promised Land received a Diverse Voices Co-Production fund award from the Corporation for Public Broadcasting and premiered on the PBS program POV in July 2010.

Untitled Gay Retiree Project
Producing Fellow: PJ Raval
Three LGBTQ seniors navigate the adventures, challenges and surprises of life and love in their golden years.?

Named one of Out Magazine?s ?Out 100 2010? and Filmmaker Magazine?s ?25 new faces of independent film 2006,? PJ Raval is an award winning filmmaker whose credits include TRINIDAD (Showtime, LOGO), The CHRISTEENE video collection (SXSW), and his current in progress documentary about LGBT seniors and retirees.

Who is Dayani Cristal?
Producing Fellow: Lucas Ochoa
The story of the quest to identify an anonymous body found in the Arizona desert whose only identifying feature is a tattoo reading ?Dayani Cristal.?

UK-based producer Lucas Ochoa is Head of Film at Pulse. His first production at Pulse Films was 2010?s No Distance Left To Run which was theatrically released internationally and went on to be nominated for a Grammy. His first documentary feature, Shut Up And Play the Hits, premiered at the 2012 Sundance Film Festival.

About the author: Eric Lavallee View all posts by Eric Lavallee

Eric Lavall?e is the founder, editor-in-chief and film critic at IONCINEMA.com (founded in 2000). Eric splits his time between his home base in Montreal, NYC, and is a regular at Sundance, Cannes and TIFF. He has a BFA in Film Studies at the Mel Hoppenheim School of Cinema. Top Films From Contemporary Film Auteurs: Almod?var (Talk to Her), Coen Bros. (Fargo), Dardennes (La Promesse), Haneke (Cach?), Hsiao-Hsien (Three Times), Kar-wai (In the Mood for Love), Kiarostami (Taste of Cherry), Lynch (Mulholland Dr.), Tarantino (Pulp Fiction), Van Sant (My Own Private Idaho), von Trier (Breaking the Waves)

Source: http://www.ioncinema.com/news/2012-sundance-institute-creative-prod-labs-bright-as-day-hellion-joy-of-living-and-life-partners

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PNC Repurchase Demands, QE3 on Aug 1?, MBA on QM, Credit ...

BillCoppedge_26Nov2011original content selection by MortgageNewsClips.com

email signup????????? Receive MNC in RSS news reader????????? me @ LinkedIn

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(GSE repurchase demands) PNC Profit Falls 40% on Costs Tied to Mortgage Putback ? Bloomberg ? ? Net income fell to $546 million, or 98 cents a share, from $912 million, or $1.67, a year earlier, the Pittsburgh-based bank said today in a statement. ? ? National Mortgage News

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(gives 3 reasons why) August 1st QE3 Departure Date? - by Bill McBride ? ? By my count, if Bernanke decides that QE3 is appropriate, he will have 10 or 11 votes on August 1st. Maybe the FOMC will wait for more data, but I think QE3 is likely very soon. ? ? Calculated Risk
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MBA Warns QM Rule Could Unduly Impede Lending ? By: Krista Franks Brock ? ? ?How it is finalized ? what it contains and how it is structured ? will determine how many consumers have access to safe, affordable and sustainable mortgage credit for generations to come,? the trade group stated in its letter to the CFPB. The MBA warned that ?without lending, the economy will not recover,? and the ability to repay/qualified mortgage (QM) rule has the potential to substantially restrict lending. ? ? The M Report
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U.S. Consumer Watchdog to Oversee Credit Bureaus ? By VICKIE ELMER ? The Consumer Financial Protection Bureau is set to announce on Monday that it will begin supervising the leading credit bureaus, the companies that collect financial details of everyone?s life. The credit bureaus join mortgage brokers, payday lenders and credit card companies among the institutions beyond banks that the bureau regulates. ? NY Times Dealbook
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The twin lost decades in housing and stocks ? baby boomers selling homes to a less affluent young American population. The impact of baby boomers on the housing market. ? Dr. Housing Bubble

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Zuckerberg?s Loan Gives New Meaning to the 1% ? By John Gittelsohn and Dakin Campbell? ? ?The Facebook Inc. (FB) founder refinanced a $5.95 million mortgage on his Palo Alto, California, home with a 30-year adjustable-rate loan starting at 1.05 percent, according to public records for the property. While almost all lending rates have reached historical lows this year, the borrowing costs available to high-net-worth individuals are even lower if the person is willing to bear the risk of monthly interest rate adjustments, said Greg McBride, senior financial analyst with Bankrate Inc. ? ?When you can borrow at a rate below inflation, you?re borrowing for free,? McBride said in an e-mail. ?This is the concept of using other people?s money and it preserves financial flexibility for the borrower.? ? ? Bloomberg

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(interesting charts and commentary) Low Mortgage Rates Stimulate Housing ? David Sims ? Seeking Alpha

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SIFMA Statement On the JPA?s Proposed Use of Eminent Domain to Take Mortgage Loans ? SIFMA Press Release

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White House Skeptical of Plan to Seize Mortgages by Eminent Domain ? WSJ Economy Stream ? The Obama administration has concerns with a proposal?backed by a one-time major fundraiser to President Barack Obama?that would use eminent domain to seize and restructure mortgages.
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Fannie Mae to train mortgage servicer single points of contact ? By Jon Prior ? Fannie Mae opened training to call center employees at mortgage servicing shops around the country. A total of 18 servicers adopted the Know Your Options Customer Care program over the last year, ? Fannie will provide scripting for receiving calls from homeowners and help installing other quality controls. Servicers with at least 1,000 delinquent Fannie loans will be asked to join the program, which will be free of charge ? ? Housingwire
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More underwater borrowers shorten mortgage under HARP ? By Jon Prior ? More Fannie Mae and Freddie Mac borrowers who owe more on their mortgage than their home is worth chose to refinance into shorter-term loans in order to rebuild equity faster, according to the Federal Housing Finance Agency. Roughly 19% of homeowners who are more than 5% underwater chose 15- and 20-year terms when offered a workout under the Home Affordable Refinance Program. That percentage is more than double the average in 2011, according to the FHFA report. ? Housingwire

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FHFA: HARP Represents 20% Of Refinance Market ? by MortgageOrb.com ? Loans connected to the Home Affordable Refinance Program (HARP) represented 20% of total refinance volume in May, the largest increase since the program was launched in 2009, according to new data from the Federal Housing Finance Agency (FHFA). ? During the first five months of this year, more than 78,000 refinances were completed, exceeding the total HARP refinances during all of 2011. In May, borrowers with greater than 105% LTV accounted for nearly one-third of HARP volume.
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(payment shocks coming) Here Comes the Catch in Home Equity Loans ? By GRETCHEN MORGENSON ? ? During the initial years of home equity credit lines, borrowers must pay only interest. ? What?s known as the initial draw period for home equity lines of credit is coming to an end for many borrowers. Soon, they will have to pay principal as well. ? While $11 billion in home equity lines are starting to require principal and interest payments this year, the amount jumps to $29 billion by 2014, the office said. That is followed by a surge to $53 billion in 2015 and $73 billion in 2017. For 2018 and beyond, it?s $111 billion. ? ? NY Times

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(lower rates is why ? charts and tables) Monthly cost of home ownership down over 50% from 2006 ? OC Housing News

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Liborgate Section: 3 more

(endless lawsuits continued) Analysis: Wall Street may face Libor legal threat from small banks ? By Tom Hals ? (Reuters) ? The thousands of community banks have often said their much larger counterparts have trampled on them. Now some hope the latest Wall Street scandal could give them ammunition to strike back.

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New York Fed to Barclays: ?Mm hmm? ? If Libor-fixing is such a great scandal, why did Geithner and other regulators do so little? ? Wall Street Journal

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House panel to probe LIBOR scandal; CalPERS might seek damages ? By Jim Puzzanghera and Marc Lifsher ? A House committee is launching a bipartisan investigation into allegations that large banks rigged a key interest rate and plans to question Federal Reserve Chairman Ben S. Bernanke and Treasury Secretary Timothy F. Geithner at upcoming hearings. At the same time, officials at the country?s largest public pension fund, the California Public Employees? Retirement System, said Monday they were examining the impact of the rate-fixing scandal and might seek damages if they could be calculated. ? LA Times

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For Rob Chrisman?s latest daily post, click here.

To subscribe to Joe Garrett?s news letter, send an email to? jgarrett at garrettmcauley dot? com

Source: http://mortgagenewsclips.com/2012/07/19/pnc-repurchase-demands-qe3-on-aug-1-mba-on-qm-credit-bureau-oversight-boomers-vs-young-zuckerbergs-1-rates-and-housing-eminent-domain-fnma-and-spoc-harp-home-equity-shocks-ho-costs-drop/

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Thursday, July 19, 2012

Emily Winters: We're Building A Patio! | The Pegboard

We?re so excited. Adding a patio space to the backyard has been a pipe dream since we designed and built the deck in 2010. The deck that extends off the back of the house is big enough for a table and chairs, but while you?re resting on it, you take a beating from the daytime sun, and we?ve been looking to build a secondary outdoor living area in a shadier part of the yard, closer to an area where we also want be grilling and having campfires.

As most time-intensive and cost-prohibitive?DIY projects start, we spent the last few weeks exploring and pricing products at local landscaping shops, and finally came up with something that would be the perfect fit for our yard. Note: It?s not what I?m vying over in this photo, it?s better.

Emily scoping out her patio stone options.

Keep on reading to learn more about our patio planning process!

This is probably the most laborious project we?re taking on during the summer months, and we?re hoping to work fast so that we can thoroughly enjoy our new patio before fall sets in. We have grand plans to carpet a larger portion of the yard in flagstone (yes! Flagstone!) over the next few years, but we wanted to start small by paving a 225 sq. ft. area in the back of our property to make sure we really liked the way it looked, and how it served as a functional surface. Flagstone in bulk gets expensive, so it seems more logical to do a test run and save up gradually as we can.

Identifying where the new patio should be installed.

Over the last few years, I?ve created a small half-circle area behind the garage and ornamented it with a tree (apple? cherry?), but the tree never really took root and always looked sickly. Time to yank it up and make better use of the space. With the half-circle space serving as inspiration, we set out to create a full, round area for the stones to sit within.

Identifying where the new patio should be installed.

As I mentioned, we shopped around for weeks, calling different local landscapers, outdoor design centers, negotiating prices, comparing what the landscapers recommended in terms of supplies, and arranging deliveries.

It?s always a good idea to go to these centers and walk around the grounds to get your hands (and feet) on the products they sell. Many retailers will stage their own landscapes as a showroom to display all sorts of pavers and stone options, making it easy to see how the products will look in real-life settings and give you some really good ideas for execution. Remember to take lots of photos while you?re exploring your options, it?ll be worth having them to look back upon when you?re home making measurements and planning your project.

For our own reference, we captured a few photos of designs and stones that looked really nice in execution.

Nice patio stone layout.

I liked the real steps made from these locking pavers; we won?t be needing steps to our new patio, but maybe someday we will in a future home. They looked so clean and geometric, and felt really solid.

If we needed to be building stairs to the patio, I liked these.

This particular cove at one of the landscaping design centers felt a lot like how we envisioned our own patio, with a nice rounded edge and a floor space large enough for a chiminea and chairs, or a table for a backyard picnic. We really liked the rock retaining wall too, but that might have to come as a Phase 2 construction detail.

Pete observing a pretty landscaping concept.

There are an overwhelming number of options when it comes to pavers and patio stones, but when you begin to consider the colors, textures, how they need to be assembled, and pricing by the palette/square foot, you?d be surprised how easily you can narrow down your decision. Nonetheless, the whole selection at one shop was really pretty and I probably would have taken any one of them home with me.

Patio paver overload.

It?s worth chatting with the professionals at these landscaping centers; I?ve found that most were willing to help a novice DIY-er and offer good tips on quantity, material, and installation. One good piece of advice was that these smaller stones were better suited for building a wall than being used as floor pavers (boo, they would have made for a very affordable flooring).

More landscaping options at a local shop.

At another shop, we seriously considered these thick, smaller pavers, so I posed in the summer lake breeze and had myself a little moment (they were $430/palette, but thicker than our flagstone option, so the whole palette wouldn?t have covered as much ground (literally):

We really liked these stones.

But ultimately, we went with our gut and buy large palettes of heavy, jagged flagstone for our own backyard oasis. The shop that we bought from, Northern Stone & Design Center in nearby Fairport, NY had a lot of inventory, an amazing on-site outdoor showroom, and stocked both the lilac-colored flagstone (in the foreground of this next picture) as well as a more rainbow colored flagstone (the palette in the back). I don?t know the specific genus and species of these flagstones, but I do know that there are easily 100 colors and varieties depending on geography, and these are just the colors we saw supplied locally.

Flagstone time!

Rainbow was our pick. We liked how it looked dry (gray undertones which would look nice beside the garage and house), and when wet, the nuances in color really begin to shine.

Pretty flagstone option.

One of the landscaping shops had offered this information as a guide for measuring the palette of stand-up broken flagstone:

  • A palette of 1? thick stones would cover 200 sq. ft.
  • A palette of 1.5? thick stones would cover 130 sq. ft.
  • A palette of 2? thick stones would cover 90 sq. ft.

Because our space was roughly 225 sq. ft. (measured as a 15?15 circle, which is ), We ordered two pallets of stone and two yards of crusher to serve as an underlay. The total cost (with delivery) totaled just under $1,100.00, and we achieved some efficiencies in delivery by ordering all materials from the same supplier. It feels like a lot to invest for a small outdoor space (especially after overhauling your entire bathroom for only $1,500.00) but we?re excited to see it begin to take shape.

Driveway, loaded.

More to come in the coming weeks! Is anyone else out there working on installing a new patio during one of the hottest summers on record?

Catching the home improvement bug at an early age, Emily Winters is a now a devoted DIYer living in Rochester, NY. The projects she covers on her blog?Merrypad?range from painting a wall to building a deck, so it?s only natural she landed at DIYNetwork.com. You can follow Emily on twitter at?@merrypad?and like her on facebook at?facebook.com/merrypad.

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Source: http://blog.diynetwork.com/tool-tips/2012/07/19/emily-winters-were-building-a-patio/

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Wednesday, July 18, 2012

Human cells, plants, worms and frogs share mechanism for organ placement

Tuesday, July 17, 2012

As organisms develop, their internal organs arrange in a consistent asymmetrical pattern--heart and stomach to the left, liver and appendix to the right. But how does this happen?

Biologists at Tufts University have produced the first evidence that a class of proteins that make up a cell's skeleton -- tubulin proteins -- drives asymmetrical patterning across a broad spectrum of species, including plants, nematode worms, frogs, and human cells, at their earliest stages of development.

"Understanding this mechanism offers insights important to the eventual diagnosis, prevention and possible repair of birth defects that result when organs are arranged abnormally," said Michael Levin, Ph.D., senior author on the paper and director of the Center for Regenerative and Developmental Biology at Tufts University's School of Arts and Sciences.

"The research also suggests that the origin of consistent asymmetry is ancient, dating back to before plants and animals independently became multicellular organisms," he added.

The work appears in the Proceedings of the National Academy of Sciences Online Early Edition publishing the week of July 16, 2012.

Co-authors with Levin are Joan M. Lemire, Ph.D.,a research associate in the Department of Biology, and doctoral student Maria Lobikin, also in the Department of Biology.

Tubulin Proteins Operate Across Species

Up to now, scientists have identified cilia?rotating hair-like structures located on the outside of cells?as having an essential role in determining where internal organs eventually end up. Scientists hypothesized that during later stages of development, cilia direct the flow of embryonic fluid which allows the embryo to distinguish its right side from its left.

But it is known that many species develop consistent left-right asymmetry without cilia being present, which suggests that asymmetry can be accomplished in other ways.

Levin's team pinpointed tubulin proteins, an important component of the cell's skeleton, or cytoskeleton. Tubulin mutations are known to affect the asymmetry of a plant called Arabidopsis, and Levin's previous work suggested the possibility that laterality is ultimately triggered by some component of the cytoskeleton. Further, this mechanism could be widely used throughout the tree of life and could function at the earliest stages of embryonic development.

In their latest experiment, the Tufts researchers injected the same mutated tubulins into early frog embryos. The resulting tadpoles were normal, except that their internal organs' positions were randomly placed on either the left or right side.

In subsequent experiments, collaborators at the University Of Illinois College Of Medicine and Cincinnati Children's Hospital Research Foundation found that mutated tubulins also have the same effect on left-right asymmetry of the nervous system in nematodes and on the function of human cells in culture.

Altogether, the Tufts experiment showed that tubulins are unique proteins in the asymmetry pathway that drive left-right patterning across the wide spectrum of separated species.

Importantly, mutated tubulins perturbed asymmetry only when they were introduced immediately after fertilization, not when they were injected after the first or second cell division. This suggested that a normal cytoskeleton drives asymmetry at extremely early stages of embryogenesis, many hours earlier than the appearance of cilia. Further, the Tufts biologists found that tubulins play a crucial role in the movement of other molecules to the left and right sides of the early embryo.

An Understanding of Birth Defects

"What's remarkable about these findings is that the same proteins are involved in establishing asymmetry in organisms as diverse as plants, nematodes, and frogs, and they even affect symmetry in human tissue culture cells," said Susan Haynes, Ph.D., of the National Institutes of Health's National Institute of General Medical Sciences, which partially funded the work. "This work is a great example of basic research that not only illuminates fundamental developmental mechanisms, but also increases our understanding of a class of serious human birth defects."

###

Tufts University: http://www.tufts.edu

Thanks to Tufts University for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/121764/Human_cells__plants__worms_and_frogs_share_mechanism_for_organ_placement

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How aging impairs immune response

ScienceDaily (July 17, 2012) ? Researchers at Albert Einstein College of Medicine of Yeshiva University have uncovered one of the mechanisms by which aging may compromise the ability of the immune system to fight infections and respond to vaccines. The study, conducted in aging mice, shows that administering antioxidants may help reverse this loss of immune function. The findings were published online this month in the journal Cell Reports.

"Aging is known to affect immune function, a phenomenon known as immunosenescence, but how this happens is not clear," said study leader Laura Santambrogio, M.D., Ph.D., associate professor of pathology and of microbiology & immunology at Einstein. "Our study has uncovered several ways in which aging can worsen the body's overall ability to mount an effective immune response."

All cells generate chemicals called free radicals as a normal part of metabolism. These highly reactive, unstable molecules can readily damage proteins, lipids and other cellular components through oxidation (the reaction between oxygen and substances it comes in contact with). Cells keep "oxidative stress" in check by producing several enzymes that are scavengers of free radicals. But in aging, increased production of free radicals coupled with cells' decreased production of antioxidant enzymes cause a buildup of damaged proteins and other molecules that can be toxic to cells.

The current study is the first to examine whether age-related oxidative stress compromises the function of a type of immune cell called dendritic cells. "Dendritic cells are known as the 'sentinels of the immune system' and alert the rest of the immune system to the presence of microbial invaders," explained Dr. Santambrogio. "When you are exposed to viruses or bacteria, these cells engulf the pathogens and present them to the immune system, saying in effect, 'There's an infection going on, and here is the culprit -- go get it.'"

Dr. Santambrogio, in collaboration with Einstein colleagues Fernando Macian-Juan, M.D., Ph.D., and Ana Maria Cuervo, M.D., Ph.D., isolated dendritic cells from aging mice and found that oxidation-damaged proteins had accumulated in those cells and had caused harmful effects. For example, oxidatively modified proteins hampered the function of endosomes, the cell's organelle where pathogens are inactivated.

When the mice were injected with a potent antioxidant in the abdominal cavity daily for two weeks, some of the effects of oxidative stress were reversed. This finding has implications for designing vaccines or therapies for humans, especially the elderly, whose weakened immune systems increase their susceptibility to infections and cancer, and reduces vaccine effectiveness. "Many elderly people respond very poorly to vaccination, so perhaps a cycle of therapy with antioxidants before vaccination might improve their immune response to vaccines," Dr. Santambrogio noted.

The paper is titled "Age-related Oxidative Stress Compromises Endosomal Proteostasis." In addition to Dr. Santambrogio, Dr. Macian-Juan, associate professor of pathology, and Dr. Cuervo, professor of developmental and molecular biology, of anatomy and structural biology and of medicine, other Einstein contributors were Elvira Cannizzo PhD candidate, Cristina Clement, Ph.D.; Kateryna Morozova, Ph.D.; Rut Valdor, Ph.D.; Susmita Kaushik PhD, Larissa Almeida PhD candidate, Carlo Follo PhD, and Ranjit Sahu, Ph.D.

The study was supported by several grants from the National Institutes of Health (NIH), including from the National Institute of Allergy and Infectious Diseases (AI48833), the National Institute on Aging (AG031782), the National Institute of Diabetes and Digestive Diseases (DK041918), and a NIH Fogarty Geographic Infectious Diseases Training Grant (D43TW007129).

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Story Source:

The above story is reprinted from materials provided by Albert Einstein College of Medicine of Yeshiva University.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Elvira?S. Cannizzo, Cristina?C. Clement, Kateryna Morozova, Rut Valdor, Susmita Kaushik, Larissa?N. Almeida, Carlo Follo, Ranjit Sahu, Ana?Maria Cuervo, Fernando Macian, Laura Santambrogio. Age-Related Oxidative Stress Compromises Endosomal Proteostasis. Cell Reports, 2012; DOI: 10.1016/j.celrep.2012.06.005

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://www.sciencedaily.com/releases/2012/07/120717162133.htm

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The Supreme Court Still Thinks Corporations Are People (Atlantic Politics Channel)

Share With Friends: Share on FacebookTweet ThisPost to Google-BuzzSend on GmailPost to Linked-InSubscribe to This Feed | Rss To Twitter | Politics - Top Stories Stories, RSS and RSS Feed via Feedzilla.

Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/237941640?client_source=feed&format=rss

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Rodent thieves explain mystery of tree survival

Thievery?by rodents moved an estimated 87 percent of seeds beyond the immediate vicinity of the parent tree, according to a study.

By Wynne Parry,?LiveScience Senior Writer / July 16, 2012

Rodents, such as rabbit-size agoutis, carry away seeds and bury them, creating caches of stored food.

Pearson Scott Foresman

Enlarge

Large-seeded trees in the American tropics have posed a mystery: How have the young trees survived, when local wildlife can?t swallow the fruits and seeds whole and transport them away from the parent tree?

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The fruits can be up to 4 inches (10 centimeters) in diameter, and researchers have proposed that, many millennia ago, the enormous animals of the Pleistocene, including the relatives of elephants and?mastodons, did the job of consuming the fruit and dropping the seeds elsewhere. But those animals are long gone, and today, smaller animals inhabit the region.

Now, scientists report they?ve found the seed spreader: thieving rodents.

Rodents, such as rabbit-size agoutis, carry away seeds and bury them, creating caches of stored food. Until now, scientists didn?t think rodents?such as agoutis?were up to the task of handling the large seeds. For one thing, the animals didn?t appear to carry the seeds far enough away from the parent tree to give seedlings a good shot at establishing themselves.

But prior work didn?t take agoutis? thieving ways into account.

An international team of researchers, led by Patrick Jansen of the Smithsonian Tropical Research Institute, followed the fate of 589 black palm seeds on Panama?s Barro Colorado Island by attaching transmitters to the roughly 1.2-inch (3-centimeter) long seeds, with the orange fruit scraped off. They also followed the movements of 16 clearly identifiable agoutis, and monitored 154 agouti caches with remote cameras for a year.

They found that the agoutis raided each others? caches, moving seeds to new locations, which were themselves then plundered by other agoutis.

One seed was hidden as many as 36 times,?traveling more than 2,460 feet (749 meters), and ending up 920 feet (280 m) from its starting point, when it was dug up and eaten 209 days later, the researchers write in results published online today (July 16) in the journal Proceedings of the National Academy of Sciences.

This thievery moved an estimated 87 percent of seeds beyond the immediate vicinity of the parent tree, according to the study.

What?s more, only a fraction of the seeds removed from the initial cache ? about 13 percent ? were eaten, and an estimated 14 percent of cached seeds survived to the next year, when new fruit became available to distract the rodents, they found.?

Rodents and large-seeded plants such as the black palm have a very old relationship that dates to before?the Pleistocene, the researchers noted.

"These plants may have a long history of seed dispersal by rodents, and perhaps never depended on megafauna (large animals) in the first place," they concluded.

Follow Wynne Parry on Twitter?@Wynne_Parry?or?LiveScience?@livescience. We're also on?Facebook?&?Google+.

Source: http://rss.csmonitor.com/~r/feeds/science/~3/PcCcGZ-M_0Y/Rodent-thieves-explain-mystery-of-tree-survival

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Business Travel: Tips When looking for brilliant low-cost package of ...

Holiday offers can be very expensive for some people, especially if they are cheap or if you do not have a lot of purchasing power. On these events, it is proposed that seek discounted travel deals. Read on as I have something extra about it.

Budget Planning

Based on my experience, is always a good strategy of the funds before you start preparing everything else. Once you have the funds, you can then move on to prepare for your actions, determining a location, etc. In general, the strategy, because the first funds that will create the rest of the preparation of a lot easier.

Visit Journey Cope Websites

The next step is to look for sites dealing with travel. These sites are often available with the existing Internet directory that guests with a wide range of travel discount offers. Visitors will not only be spoiled for options, but must also be able to compare the cost to be between the different deals.

Another advantage of discount offers to search for travel on the Internet is that you also get to do some research on different locations that are in another country to visit for. As such, it will also be able to assess the costs among the resort, the resort scores. In simple terms, you will get a better picture of each village and you can create a better decision from there.

Fly When Off-Peak

If you are not traveling to the nation of his position to obtain a certain occasion, you may want to consider traveling during the peak period. This is due to the fact that you make some deals given to many a much lower price. Not only that, but usually do not see a lot of tourists at the moment. As such, there is no need to contest, with an audience of other tourists when you're organizing your entry, viewing tourism opportunities or to arrange an accommodation. This goes to those who do not like large crowds of people and then have fun with the whole living room or refreshment to themselves.

Other places you can look

Finally, you could look out for all the coupons provided by organizations or commercial airlines offers provided by your card company credit scores. If you are a client of a particular organization dedicated commercial airline, the airline trade organization could exist with coupons that can be used with their rates. In addition, some creditors provide their loyal customers with offset points, which can in turn use to receive offers, as the program offers travel.

We hope to have a better picture of how you can book your travel discount offers on the Internet. With this, I wish you a pleasant holiday, and we appreciate your vacation!

Source: http://boudicaofsuburbia.blogspot.com/2012/07/tips-when-looking-for-brilliant-low.html

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New way to induce programmed cell death, or apoptosis

ScienceDaily (July 17, 2012) ? Researchers from the Hebrew University of Jerusalem and the Weizmann Institute of Science have developed a technique to cause apoptosis, or programmed cell death, that could lead to new approaches to treating cancer.

Apoptosis is an essential defense mechanism against the spread of abnormal cells such as cancer. It is a complex process that occurs through networks of proteins that interact with each other. Cancer cells usually avoid this process due to mutations in the genes that encode the relevant proteins. The result is that the cancer cells survive and take over while healthy cells die.

The research, by graduate student Chen Hener-Katz at the Hebrew University, involved collaboration between Prof. Assaf Friedler of the Hebrew University's Institute of Chemistry and Prof. Atan Gross of the Weizmann Institute's Department of Biological Regulation. It was published in the Journal of Biological Chemistry under the title ''Molecular Basis of the Interaction between Proapoptotic Truncated BID (tBID) Protein and Mitochondrial Carrier Homologue 2 (MTCH2) Protein.''

The study examined the interaction between two important proteins involved in cell death: mitochondrial carrier homologue 2 (MTCH2), which was discovered in the lab of Prof. Gross, and truncated BID (tBID), which are both involved in the apoptotic process. The researchers found the regions in the two proteins that are responsible for binding to each other, a critical step in initiating apoptosis. Following their discovery, the researchers developed short synthetic protein fragments, or peptides, that mimicked the areas on the proteins that bind to each other, and by doing so inhibited this binding. In lab experiments conducted on cell cultures, this resulted in the death of cancer cells of human origin.

''These protein segments could be the basis of future anti-cancer therapies in cases where the mechanism of natural cell death is not working properly,'' said Prof. Friedler. ''We have just begun to uncover the hidden potential in the interaction between these proteins. This is an important potential target for the development of anticancer drugs that will stimulate apoptosis by interfering with its regulation. ''

Prof. Friedler is the head of the school of chemistry at the Hebrew University. His major research interests are using peptides to study protein-protein interactions in health and disease, and developing peptides as drug leads that modulate these interactions, specifically in relation to HIV and cancer. Prof. Friedler won the prestigious starting grant from the ERC (European Research Council) as well as the outstanding young scientist prize by the Israeli Chemical Society. His research was supported by a grant from the Israel Ministry of Health and by a starting grant from the European Research Council.

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The above story is reprinted from materials provided by The Hebrew University of Jerusalem.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. C. Katz, Y. Zaltsman-Amir, Y. Mostizky, N. Kollet, A. Gross, A. Friedler. Molecular Basis of the Interaction between Proapoptotic Truncated BID (tBID) Protein and Mitochondrial Carrier Homologue 2 (MTCH2) Protein: KEY PLAYERS IN MITOCHONDRIAL DEATH PATHWAY. Journal of Biological Chemistry, 2012; 287 (18): 15016 DOI: 10.1074/jbc.M111.328377

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://www.sciencedaily.com/releases/2012/07/120717100237.htm

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